Two sample MR report

Telomere_length against IDP dMRI TBSS ISOVF Tapetum L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0963578	0.1003894	0.3480571
Weighted median	23	-0.0312205	0.0539582	0.5628556
Inverse variance weighted	23	0.0150508	0.0392331	0.7012576
Simple mode	23	0.2206426	0.0959069	0.0312696
Weighted mode	23	-0.0396758	0.0612943	0.5241358

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.93362	21	0.7733688
Inverse variance weighted	17.38721	22	0.7416395

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.006841	0.0056741	0.2413627

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005313	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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