Two sample MR report

Telomere_length against IDP dMRI TBSS ISOVF Sagittal stratum R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0241916	0.1282605	0.8522070
Weighted median	23	-0.0159928	0.0600124	0.7898609
Inverse variance weighted	23	0.0094360	0.0490676	0.8475018
Simple mode	23	-0.0934092	0.1067247	0.3909019
Weighted mode	23	-0.0399835	0.0588055	0.5036422

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.27979	21	0.0338164
Inverse variance weighted	34.41222	22	0.0445805

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0020649	0.0072494	0.7785608

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010445	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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