Two sample MR report

Telomere_length against IDP dMRI TBSS ISOVF Sagittal stratum L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1296459	0.1055296	0.2328398
Weighted median	23	-0.0359978	0.0550297	0.5130138
Inverse variance weighted	23	-0.0063995	0.0418098	0.8783495
Simple mode	23	-0.0746603	0.0854256	0.3915701
Weighted mode	23	-0.0498797	0.0613373	0.4248151

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.20595	21	0.3330968
Inverse variance weighted	24.98488	22	0.2977982

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0075679	0.0059646	0.2183997

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007578	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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