Two sample MR report

Telomere_length against IDP dMRI TBSS ISOVF Pontine crossing tract

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1181594	0.1070153	0.2820254
Weighted median	23	-0.0275210	0.0624799	0.6595912
Inverse variance weighted	23	0.0092199	0.0424567	0.8280842
Simple mode	23	-0.0156776	0.1123043	0.8902470
Weighted mode	23	-0.0221454	0.0945174	0.8169193

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.86437	21	0.2996766
Inverse variance weighted	25.76464	22	0.2619242

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0078218	0.0060487	0.2100109

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007824	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8