Two sample MR report

Telomere_length against IDP dMRI TBSS ISOVF Middle cerebellar peduncle

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2665920	0.1029074	0.0170634
Weighted median	23	0.1653414	0.0574210	0.0039836
Inverse variance weighted	23	0.0897863	0.0424273	0.0343243
Simple mode	23	0.1984723	0.1026008	0.0660262
Weighted mode	23	0.1826899	0.0644561	0.0096515

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.06821	21	0.3955883
Inverse variance weighted	25.72945	22	0.2634792

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0108569	0.0058165	0.075991

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009384	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8