Two sample MR report

Telomere_length against IDP dMRI TBSS ISOVF Medial lemniscus R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0711195	0.1073423	0.5148263
Weighted median	23	0.0255495	0.0599434	0.6699428
Inverse variance weighted	23	-0.0228517	0.0418592	0.5851223
Simple mode	23	0.0507517	0.1132315	0.6583832
Weighted mode	23	0.0351713	0.0735180	0.6370827

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.00978	21	0.2925848
Inverse variance weighted	25.04396	22	0.2949772

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0057703	0.0060671	0.3523869

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007692	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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