Two sample MR report

Telomere_length against IDP dMRI TBSS ISOVF Medial lemniscus L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0139425	0.1104254	0.9007262
Weighted median	23	0.0436756	0.0607616	0.4722630
Inverse variance weighted	23	0.0013919	0.0421784	0.9736745
Simple mode	23	0.0657522	0.1015361	0.5239608
Weighted mode	23	0.0657522	0.0761900	0.3974462

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.40902	21	0.2298838
Inverse variance weighted	25.42747	22	0.2770727

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0007707	0.0062414	0.9029041

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007706	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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