Two sample MR report

Telomere_length against IDP dMRI TBSS ISOVF Fornix

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0455477	0.1222441	0.7131828
Weighted median	23	0.0052302	0.0608147	0.9314644
Inverse variance weighted	23	-0.0106666	0.0467832	0.8196459
Simple mode	23	0.0265983	0.1179109	0.8236109
Weighted mode	23	0.0126483	0.0820518	0.8788970

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.14076	21	0.0713470
Inverse variance weighted	31.28326	22	0.0904633

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0021419	0.0069094	0.7596208

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009502	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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