Two sample MR report

Telomere_length against IDP dMRI TBSS ISOVF External capsule R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0202069	0.1293210	0.8773255
Weighted median	23	-0.0123911	0.0601183	0.8367035
Inverse variance weighted	23	0.0156717	0.0493790	0.7509583
Simple mode	23	-0.1331049	0.1068152	0.2258260
Weighted mode	23	-0.0438140	0.0740875	0.5602932

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.84894	21	0.0293315
Inverse variance weighted	34.85135	22	0.0401528

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0002785	0.0073094	0.9699686

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010608	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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