Two sample MR report

Telomere_length against IDP dMRI TBSS ISOVF External capsule L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0020831	0.1136890	0.9855543
Weighted median	23	0.0138075	0.0607063	0.8200760
Inverse variance weighted	23	0.0241801	0.0434739	0.5780756
Simple mode	23	-0.0056076	0.1205800	0.9633274
Weighted mode	23	-0.0027670	0.0799339	0.9726980

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.93316	21	0.1730767
Inverse variance weighted	27.01394	22	0.2106976

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0016127	0.0064259	0.8042782

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008301	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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