Two sample MR report

Telomere_length against IDP dMRI TBSS ISOVF Cingulum hippocampus L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0741817	0.1003881	0.4681173
Weighted median	23	0.0536307	0.0572914	0.3492199
Inverse variance weighted	23	0.0419997	0.0392329	0.2843832
Simple mode	23	0.0101229	0.0902633	0.9117226
Weighted mode	23	0.0608409	0.0659743	0.3664323

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.94750	21	0.8255770
Inverse variance weighted	15.06879	22	0.8592689

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0019761	0.0056741	0.7311018

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004914	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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