Two sample MR report

Telomere_length against IDP dMRI TBSS ISOVF Cingulum cingulate gyrus R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0159238	0.1227393	0.8980094
Weighted median	23	-0.0332793	0.0578392	0.5650370
Inverse variance weighted	23	0.0353278	0.0468977	0.4512730
Simple mode	23	0.1408739	0.1092494	0.2106267
Weighted mode	23	-0.0140486	0.0732495	0.8496648

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.39225	21	0.0673731
Inverse variance weighted	31.43634	22	0.0875264

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0011915	0.0069374	0.8652785

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009771	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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