Two sample MR report

Telomere_length against IDP dMRI TBSS ISOVF Cingulum cingulate gyrus L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0144376	0.1218713	0.9068246
Weighted median	23	0.1299272	0.0634049	0.0404457
Inverse variance weighted	23	0.1282560	0.0476601	0.0071226
Simple mode	23	0.1861847	0.1292947	0.1639462
Weighted mode	23	0.1801050	0.0850475	0.0457371

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.95017	21	0.0744913
Inverse variance weighted	32.46737	22	0.0697697

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.006989	0.0068883	0.3218384

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013076	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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