Two sample MR report

Telomere_length against IDP dMRI TBSS ISOVF Cerebral peduncle R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1397889	0.1019378	0.1847534
Weighted median	23	0.1077303	0.0551626	0.0508243
Inverse variance weighted	23	0.1278681	0.0392327	0.0011172
Simple mode	23	0.1080071	0.0977541	0.2811469
Weighted mode	23	0.0913342	0.0654805	0.1769917

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.65304	21	0.4197341
Inverse variance weighted	21.66969	22	0.4797460

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.000732	0.0057617	0.9001137

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009785	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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