Two sample MR report

Telomere_length against IDP dMRI TBSS ISOVF Cerebral peduncle L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0629304	0.1003886	0.5375017
Weighted median	23	0.0882591	0.0547059	0.1066714
Inverse variance weighted	23	0.1142650	0.0392329	0.0035857
Simple mode	23	0.1117116	0.0895487	0.2253323
Weighted mode	23	0.0674515	0.0638085	0.3019397

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	9.82088	21	0.9811450
Inverse variance weighted	10.12950	22	0.9850921

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0031522	0.0056741	0.5843958

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000564	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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