Two sample MR report

Telomere_length against IDP dMRI TBSS ICVF Uncinate fasciculus R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2136918	0.1221126	0.0947254
Weighted median	23	-0.1463652	0.0629458	0.0200583
Inverse variance weighted	23	-0.1810188	0.0467185	0.0001068
Simple mode	23	-0.2445271	0.1046787	0.0290086
Weighted mode	23	-0.1062104	0.0825161	0.2114209

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.07320	21	0.0724482
Inverse variance weighted	31.19823	22	0.0921300

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0020063	0.0069021	0.7741466

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015901	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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