Two sample MR report

Telomere_length against IDP dMRI TBSS ICVF Uncinate fasciculus L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0678695	0.1381060	0.6282188
Weighted median	23	-0.1269339	0.0583190	0.0295145
Inverse variance weighted	23	-0.1814274	0.0537240	0.0007327
Simple mode	23	-0.1347348	0.0918328	0.1564796
Weighted mode	23	-0.1234653	0.0648762	0.0701958

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.74514	21	0.0079856
Inverse variance weighted	41.25540	22	0.0076829

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.006973	0.007806	0.3818244

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0018976	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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