Two sample MR report

Telomere_length against IDP dMRI TBSS ICVF Tapetum R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.3398652	0.1357389	0.0206076
Weighted median	23	-0.1525394	0.0584859	0.0091036
Inverse variance weighted	23	-0.1815036	0.0537736	0.0007373
Simple mode	23	-0.0932965	0.0962923	0.3431331
Weighted mode	23	-0.1688656	0.0605345	0.0106854

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.39560	21	0.0115791
Inverse variance weighted	41.33279	22	0.0075209

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0097243	0.0076723	0.2188657

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0019002	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8