Two sample MR report

Telomere_length against IDP dMRI TBSS ICVF Tapetum L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2554749	0.1611860	0.1279178
Weighted median	23	-0.1747416	0.0563018	0.0019114
Inverse variance weighted	23	-0.1672380	0.0620603	0.0070438
Simple mode	23	-0.1254894	0.1017281	0.2303783
Weighted mode	23	-0.1517645	0.0632882	0.0254056

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	54.14141	21	0.0000942
Inverse variance weighted	55.05328	22	0.0001167

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0054182	0.0091105	0.5583859

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0022179	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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