Two sample MR report

Telomere_length against IDP dMRI TBSS ICVF Sagittal stratum R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.3424995	0.1723055	0.0600349
Weighted median	23	-0.2161867	0.0587531	0.0002336
Inverse variance weighted	23	-0.2850705	0.0659940	0.0000156
Simple mode	23	-0.1934412	0.0974152	0.0596642
Weighted mode	23	-0.2149390	0.0593505	0.0015110

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	61.87206	21	6.60e-06
Inverse variance weighted	62.25835	22	1.03e-05

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0035265	0.0097391	0.7209011

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0034852	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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