Two sample MR report

Telomere_length against IDP dMRI TBSS ICVF Sagittal stratum L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2534021	0.1783614	0.1700763
Weighted median	23	-0.1841885	0.0622119	0.0030698
Inverse variance weighted	23	-0.2577745	0.0681019	0.0001536
Simple mode	23	-0.0788448	0.0925919	0.4036491
Weighted mode	23	-0.1646181	0.0666892	0.0218171

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	66.29473	21	1.4e-06
Inverse variance weighted	66.29697	22	2.5e-06

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0002685	0.0100813	0.9790042

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0033157	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8