Two sample MR report

Telomere_length against IDP dMRI TBSS ICVF Pontine crossing tract

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1460673	0.1265805	0.2614859
Weighted median	23	-0.0192964	0.0613981	0.7533059
Inverse variance weighted	23	-0.0015720	0.0500700	0.9749535
Simple mode	23	0.1519929	0.1002289	0.1436419
Weighted mode	23	-0.0307751	0.0830167	0.7143990

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.38812	21	0.0420867
Inverse variance weighted	35.83338	22	0.0316380

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0088727	0.0071545	0.2285964

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010857	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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