Two sample MR report

Telomere_length against IDP dMRI TBSS ICVF Middle cerebellar peduncle

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2348894	0.1371189	0.1014332
Weighted median	23	-0.1047884	0.0583042	0.0722927
Inverse variance weighted	23	-0.1130415	0.0535044	0.0346222
Simple mode	23	-0.1222077	0.1055366	0.2592955
Weighted mode	23	-0.1087368	0.0680994	0.1245898

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.17926	21	0.0093425
Inverse variance weighted	40.91808	22	0.0084280

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0074821	0.0077502	0.3453285

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014913	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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