Two sample MR report

Telomere_length against IDP dMRI TBSS ICVF Medial lemniscus R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1783920	0.1113256	0.1239957
Weighted median	23	-0.0819526	0.0569197	0.1499257
Inverse variance weighted	23	-0.0730318	0.0435638	0.0936532
Simple mode	23	-0.1236128	0.0913950	0.1899508
Weighted mode	23	-0.1029157	0.0632195	0.1177822

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.82553	21	0.2131799
Inverse variance weighted	27.12562	22	0.2064942

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0064696	0.0062923	0.3155607

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000927	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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