Two sample MR report

Telomere_length against IDP dMRI TBSS ICVF Medial lemniscus L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1605818	0.1238418	0.2088130
Weighted median	23	-0.0796653	0.0633198	0.2083406
Inverse variance weighted	23	-0.0543069	0.0482547	0.2604104
Simple mode	23	-0.0533395	0.1131486	0.6419884
Weighted mode	23	-0.1032328	0.0878050	0.2522795

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.95975	21	0.0591017
Inverse variance weighted	33.28255	22	0.0580084

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0065258	0.0069997	0.3617796

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010666	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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