Two sample MR report

Telomere_length against IDP dMRI TBSS ICVF Fornix

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0177894	0.1030843	0.8646407
Weighted median	23	-0.0623493	0.0548863	0.2559683
Inverse variance weighted	23	-0.0532892	0.0398823	0.1814970
Simple mode	23	-0.0880135	0.0928593	0.3535188
Weighted mode	23	-0.0727729	0.0651253	0.2758665

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.14294	21	0.3913132
Inverse variance weighted	22.73462	22	0.4168419

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0043646	0.0058265	0.4621106

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007448	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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