Two sample MR report

Telomere_length against IDP dMRI TBSS ICVF External capsule R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2056035	0.1408575	0.1591830
Weighted median	23	-0.1358958	0.0567596	0.0166550
Inverse variance weighted	23	-0.1833501	0.0538199	0.0006574
Simple mode	23	-0.1792116	0.0945952	0.0713774
Weighted mode	23	-0.1401283	0.0598643	0.0287144

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	41.3451	21	0.0050808
Inverse variance weighted	41.4031	22	0.0073764

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0013665	0.0079615	0.8653682

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0019158	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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