Two sample MR report

Telomere_length against IDP dMRI TBSS ICVF External capsule L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1690349	0.1297968	0.2069152
Weighted median	23	-0.1151211	0.0578519	0.0465987
Inverse variance weighted	23	-0.1708071	0.0495592	0.0005678
Simple mode	23	-0.0890398	0.0863605	0.3137315
Weighted mode	23	-0.1096821	0.0618656	0.0900913

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.10624	21	0.0274863
Inverse variance weighted	35.10661	22	0.0377627

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0001088	0.0073363	0.9883054

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0016377	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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