Two sample MR report

Telomere_length against IDP dMRI TBSS ICVF Cingulum hippocampus R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2898596	0.1251326	0.0307259
Weighted median	23	-0.1352768	0.0667421	0.0426768
Inverse variance weighted	23	-0.1741827	0.0489123	0.0003693
Simple mode	23	-0.0253823	0.1124113	0.8234427
Weighted mode	23	-0.0579991	0.0907009	0.5291303

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.63015	21	0.0504825
Inverse variance weighted	34.19736	22	0.0469002

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0071032	0.0070728	0.326665

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0016332	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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