Two sample MR report

Telomere_length against IDP dMRI TBSS ICVF Cingulum hippocampus L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1900732	0.1219543	0.1340440
Weighted median	23	-0.1221419	0.0611801	0.0458869
Inverse variance weighted	23	-0.1327252	0.0468535	0.0046147
Simple mode	23	-0.1176187	0.1017559	0.2601249
Weighted mode	23	-0.1311201	0.0673332	0.0643708

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.99308	21	0.0737731
Inverse variance weighted	31.37827	22	0.0886310

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0035215	0.0068931	0.6147706

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012975	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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