Two sample MR report

Telomere_length against IDP dMRI TBSS ICVF Cingulum cingulate gyrus R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2397084	0.1385922	0.0983757
Weighted median	23	-0.1675984	0.0602152	0.0053806
Inverse variance weighted	23	-0.1797486	0.0531950	0.0007274
Simple mode	23	-0.1541226	0.0988360	0.1331777
Weighted mode	23	-0.1587260	0.0753733	0.0468548

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	40.02694	21	0.0073809
Inverse variance weighted	40.44801	22	0.0095794

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0036819	0.0078335	0.6431896

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0018613	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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