Two sample MR report

Telomere_length against IDP dMRI TBSS ICVF Cingulum cingulate gyrus L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1839844	0.1425338	0.2107994
Weighted median	23	-0.1458605	0.0649449	0.0247098
Inverse variance weighted	23	-0.1474193	0.0545230	0.0068551
Simple mode	23	-0.2498269	0.1028899	0.0238097
Weighted mode	23	-0.1566733	0.0824125	0.0704701

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	42.33577	21	0.0038172
Inverse variance weighted	42.49236	22	0.0054461

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0022453	0.0080563	0.783201

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0017153	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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