Two sample MR report

Telomere_length against IDP dMRI TBSS ICVF Cerebral peduncle R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2247438	0.1633399	0.1833423
Weighted median	23	-0.1266187	0.0586281	0.0307964
Inverse variance weighted	23	-0.0775692	0.0637745	0.2238691
Simple mode	23	-0.1102138	0.0959662	0.2631111
Weighted mode	23	-0.1235749	0.0615308	0.0570391

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	55.59818	21	5.78e-05
Inverse variance weighted	58.13507	22	4.20e-05

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0090371	0.0092321	0.3387812

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0018796	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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