Two sample MR report

Telomere_length against IDP dMRI TBSS ICVF Cerebral peduncle L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1347929	0.1619418	0.4145751
Weighted median	23	-0.0943208	0.0560534	0.0924341
Inverse variance weighted	23	-0.0861836	0.0619901	0.1644440
Simple mode	23	-0.1100035	0.0857567	0.2129338
Weighted mode	23	-0.0981145	0.0585108	0.1077233

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	54.64977	21	0.0000795
Inverse variance weighted	54.92651	22	0.0001217

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0029848	0.009153	0.7475764

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0018103	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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