Two sample MR report

Telomere_length against IDP dMRI TBSS FA Uncinate fasciculus R

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1673137	0.1123737	0.1513777
Weighted median	23	-0.0658913	0.0622163	0.2895687
Inverse variance weighted	23	-0.0990197	0.0433496	0.0223591
Simple mode	23	-0.0053938	0.1028147	0.9586348
Weighted mode	23	-0.0363930	0.0738839	0.6271964

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.31443	21	0.1947125
Inverse variance weighted	26.86068	22	0.2165659

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0041936	0.0063516	0.5162728

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001007	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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