Two sample MR report

Telomere_length against IDP dMRI TBSS FA Uncinate fasciculus L

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0465257	0.1374722	0.7383941
Weighted median	23	-0.0751808	0.0613370	0.2203113
Inverse variance weighted	23	-0.0691268	0.0535232	0.1965196
Simple mode	23	-0.1163898	0.1021532	0.2668048
Weighted mode	23	-0.0899751	0.0822697	0.2859348

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.38202	21	0.0088332
Inverse variance weighted	40.94854	22	0.0083580

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0071016	0.0077701	0.3711113

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013347	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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