Two sample MR report

Telomere_length against IDP dMRI TBSS FA Tapetum R

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1185459	0.1351019	0.3901674
Weighted median	23	-0.0425136	0.0582089	0.4651689
Inverse variance weighted	23	-0.1114517	0.0515886	0.0307422
Simple mode	23	-0.1028265	0.1056053	0.3407974
Weighted mode	23	-0.0533375	0.0760272	0.4903103

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.03596	21	0.0127641
Inverse variance weighted	38.04185	22	0.0181247

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0004356	0.0076362	0.9550471

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013971	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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