Two sample MR report

Telomere_length against IDP dMRI TBSS FA Tapetum L

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0536533	0.1413890	0.7081469
Weighted median	23	-0.0757324	0.0561832	0.1776729
Inverse variance weighted	23	-0.0810186	0.0540420	0.1338275
Simple mode	23	0.0341511	0.0961750	0.7259010
Weighted mode	23	-0.0349946	0.0595825	0.5629613

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	41.65811	21	0.0046441
Inverse variance weighted	41.74581	22	0.0067089

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0016804	0.0079915	0.835485

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013941	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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