Two sample MR report

Telomere_length against IDP dMRI TBSS FA Sagittal stratum R

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1792803	0.1488331	0.2417690
Weighted median	23	-0.1119849	0.0576426	0.0520470
Inverse variance weighted	23	-0.1920007	0.0568389	0.0007302
Simple mode	23	-0.0201926	0.0817470	0.8071886
Weighted mode	23	-0.0956865	0.0571506	0.1082336

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	46.16116	21	0.0012163
Inverse variance weighted	46.18011	22	0.0018747

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0007811	0.0084123	0.9269012

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0021247	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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