Two sample MR report

Telomere_length against IDP dMRI TBSS FA Sagittal stratum L

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0916723	0.1500451	0.5477795
Weighted median	23	-0.0540384	0.0600272	0.3679973
Inverse variance weighted	23	-0.1429373	0.0574776	0.0128884
Simple mode	23	-0.0320217	0.0907356	0.7275135
Weighted mode	23	-0.0463984	0.0595872	0.4444725

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	46.91522	21	0.0009641
Inverse variance weighted	47.22303	22	0.0013725

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0031479	0.0084808	0.7142197

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0018328	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8