Two sample MR report

Telomere_length against IDP dMRI TBSS FA Pontine crossing tract

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0618667	0.1003861	0.5443282
Weighted median	23	-0.0261864	0.0640618	0.6827103
Inverse variance weighted	23	-0.0296378	0.0392320	0.4499794
Simple mode	23	0.0658872	0.1168222	0.5784621
Weighted mode	23	-0.0625220	0.0872962	0.4813989

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.27061	21	0.5041833
Inverse variance weighted	20.39226	22	0.5585175

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.001979	0.005674	0.7307213

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006352	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8