Two sample MR report

Telomere_length against IDP dMRI TBSS FA Middle cerebellar peduncle

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2592542	0.1211971	0.0443322
Weighted median	23	-0.1204456	0.0564861	0.0329817
Inverse variance weighted	23	-0.1602475	0.0471359	0.0006746
Simple mode	23	-0.0821570	0.0977043	0.4094651
Weighted mode	23	-0.1177265	0.0690375	0.1022290

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.61046	21	0.0803897
Inverse variance weighted	31.75855	22	0.0816066

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0060796	0.0068503	0.3848686

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014678	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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