Two sample MR report

Telomere_length against IDP dMRI TBSS FA Medial lemniscus R

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0813789	0.1003869	0.4266576
Weighted median	23	-0.0507152	0.0558415	0.3637730
Inverse variance weighted	23	-0.0768472	0.0392323	0.0501392
Simple mode	23	-0.0588250	0.0964369	0.5481218
Weighted mode	23	-0.0523452	0.0578566	0.3754040

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.64192	21	0.4809901
Inverse variance weighted	20.64432	22	0.5428026

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0002783	0.005674	0.9613487

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007418	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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