Two sample MR report

Telomere_length against IDP dMRI TBSS FA Medial lemniscus L

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1028384	0.1085592	0.3542588
Weighted median	23	-0.0652898	0.0571846	0.2535632
Inverse variance weighted	23	-0.0809804	0.0414980	0.0510060
Simple mode	23	-0.1212440	0.1059379	0.2647234
Weighted mode	23	-0.0649719	0.0651106	0.3291920

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.55863	21	0.2667856
Inverse variance weighted	24.61459	22	0.3158581

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0013422	0.0061359	0.8289623

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000875	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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