Two sample MR report

Telomere_length against IDP dMRI TBSS FA Fornix

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0006214	0.1141795	0.9957088
Weighted median	23	-0.0220347	0.0614930	0.7200975
Inverse variance weighted	23	-0.0355519	0.0437116	0.4160295
Simple mode	23	-0.0671932	0.1034052	0.5225464
Weighted mode	23	-0.0448511	0.0795690	0.5786763

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.16829	21	0.1653518
Inverse variance weighted	27.31120	22	0.1996444

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0021449	0.0064536	0.7429127

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008525	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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