Two sample MR report

Telomere_length against IDP dMRI TBSS FA External capsule R

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1235240	0.1225419	0.3249219
Weighted median	23	-0.0936560	0.0565118	0.0974622
Inverse variance weighted	23	-0.1531728	0.0468660	0.0010819
Simple mode	23	-0.0857157	0.0865927	0.3329992
Weighted mode	23	-0.0893590	0.0599925	0.1505520

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.29256	21	0.0689250
Inverse variance weighted	31.39551	22	0.0883019

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0018206	0.0069262	0.7952257

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014129	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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