Two sample MR report

Telomere_length against IDP dMRI TBSS FA External capsule L

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0928889	0.1098350	0.4072464
Weighted median	23	-0.0850377	0.0572282	0.1372945
Inverse variance weighted	23	-0.1366531	0.0421243	0.0011785
Simple mode	23	-0.0810948	0.0878849	0.3661531
Weighted mode	23	-0.0661167	0.0605663	0.2868020

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.13912	21	0.2411889
Inverse variance weighted	25.36344	22	0.2800123

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0026873	0.006208	0.6695148

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011361	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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