Two sample MR report

Telomere_length against IDP dMRI TBSS FA Cingulum hippocampus R

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1877621	0.1290822	0.1605667
Weighted median	23	-0.0715768	0.0683132	0.2947423
Inverse variance weighted	23	-0.0796714	0.0502483	0.1128405
Simple mode	23	0.0107502	0.1128703	0.9249832
Weighted mode	23	-0.0338007	0.0812964	0.6816047

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.72258	21	0.0302782
Inverse variance weighted	36.09098	22	0.0296914

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0066373	0.007296	0.3732899

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012185	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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