Two sample MR report

Telomere_length against IDP dMRI TBSS FA Cingulum hippocampus L

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2824082	0.1254164	0.0351680
Weighted median	23	-0.1112438	0.0601117	0.0642244
Inverse variance weighted	23	-0.0957193	0.0507815	0.0594400
Simple mode	23	-0.0914124	0.1264472	0.4773394
Weighted mode	23	-0.1332207	0.0714566	0.0756699

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.77903	21	0.0487255
Inverse variance weighted	36.86114	22	0.0244991

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0114637	0.0070888	0.1207665

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012973	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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