Two sample MR report

Telomere_length against IDP dMRI TBSS FA Cingulum cingulate gyrus R

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1358156	0.1501740	0.3760483
Weighted median	23	-0.1446353	0.0612261	0.0181612
Inverse variance weighted	23	-0.1318153	0.0573417	0.0215180
Simple mode	23	0.0465529	0.1193277	0.7001947
Weighted mode	23	-0.1436092	0.0825006	0.0957054

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	46.99989	21	0.0009392
Inverse variance weighted	47.00176	22	0.0014669

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0002456	0.0084881	0.9771859

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0017661	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8